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Heparin is a glycosoaminoglycan that is a naturally
produced substance. It has an anticoagulation effect by inhibiting the
formation of fibrin clots. Heparin acts primarily at the following sites
in the normal coagulation system
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Combines with antithrombin III (heparin
cofactor) to accerate the neurtralization of thrombin which prevents
conversion of fibrinogen to fibrin
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Inactivates factor X which prevent conversion
of prothrombin to thrombin
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Prevents the formation of a stable fibrin
clot by inhibiting the activation of fibrin-stabilizing factor.
Heparin does not have fibrinolytic activity,
therefore, it will not lyse existing clots.
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